Progress update from the hippocampal subfields group

Published on Dec 1, 2019in Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
· DOI :10.1016/J.DADM.2019.04.001
Rosanna K. Olsen24
Estimated H-index: 24
Valerie A. Carr13
Estimated H-index: 13
(SJSU: San Jose State University)
+ 43 AuthorsLaura E.M. Wisse19
Estimated H-index: 19
(UPenn: University of Pennsylvania)
Introduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods: Our international working group, funded by the EU Joint Programme–Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results: This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion: A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide. © 2019 The Authors (Less)
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