Abstract 409: LRRC10 Associates With and Regulates Cardiac Ca V 1.2 L-type Ca 2+ Channels, and I195T LRRC10 Variant is Linked to Dilated Cardiomyopathy
Abstract
Leucine-rich repeat containing (LRR) proteins facilitate protein-protein interactions critical in a number of cellular functions including ion channel regulation. Leucine-rich repeat containing protein 10 (LRRC10), a cardiac-specific protein expressed in zebrafish, mice and humans, is essential for normal cardiac physiology with loss of Lrrc10 in Lrrc10 -/- mice resulting in dilated cardiomyopathy (DCM). However, the mechanism by which LRRC10...
Paper Details
Title
Abstract 409: LRRC10 Associates With and Regulates Cardiac Ca V 1.2 L-type Ca 2+ Channels, and I195T LRRC10 Variant is Linked to Dilated Cardiomyopathy
Published Date
Jul 21, 2017
Journal
Volume
121
Issue
suppl_1
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