c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration

Volume: 10, Issue: 6
Published: Jun 4, 2019
Abstract
An overdose of Isoproterenol (ISO) causes acute cardiomyocyte (CM) dropout and activates the resident cardiac c-kitpos stem/progenitor cells (CSCs) generating a burst of new CM formation that replaces those lost to ISO. Recently, unsuccessful attempts to reproduce these findings using c-kitCre knock-in (KI) mouse models were reported. We tested whether c-kit haploinsufficiency in c-kitCreKI mice was the cause of the discrepant results in...
Paper Details
Title
c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration
Published Date
Jun 4, 2019
Journal
Volume
10
Issue
6
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