Synergistic effect of functionalized poly( -lactide) with surface-modified MgO and chitin whiskers on osteogenesis in vivo and in vitro

Favorable cytocompatibility and osteogenesis potential are critical for the development of a bone repair material. In this study, two types of surface-modified whiskers, grafted magnesia and chitin (g-MgO and g-CHN) whiskers, were synthesized and introduced into a poly(l-lactide) (PLLA) matrix singly or together to prepare PLLA/g-MgO/g-CHN composite films and bone nails via injection molding. On the account of the synergetic contribution of...