Original paper

Disordered RNA chaperones can enhance nucleic acid folding via local charge screening

Volume: 10, Issue: 1
Published: Jun 5, 2019
Abstract
RNA chaperones are proteins that aid in the folding of nucleic acids, but remarkably, many of these proteins are intrinsically disordered. How can these proteins function without a well-defined three-dimensional structure? Here, we address this question by studying the hepatitis C virus core protein, a chaperone that promotes viral genome dimerization. Using single-molecule fluorescence spectroscopy, we find that this positively charged...
Paper Details
Title
Disordered RNA chaperones can enhance nucleic acid folding via local charge screening
Published Date
Jun 5, 2019
Volume
10
Issue
1
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