Original paper

Mitochondrial fusion regulates lipid homeostasis and stem cell maintenance in the Drosophila testis

Volume: 21, Issue: 6, Pages: 710 - 720
Published: Jun 1, 2019
Abstract
The capacity of stem cells to self-renew or differentiate has been attributed to distinct metabolic states. A genetic screen targeting regulators of mitochondrial dynamics revealed that mitochondrial fusion is required for the maintenance of male germline stem cells (GSCs) in Drosophila melanogaster. Depletion of Mitofusin (dMfn) or Opa1 led to dysfunctional mitochondria, activation of Target of rapamycin (TOR) and a marked accumulation of lipid...
Paper Details
Title
Mitochondrial fusion regulates lipid homeostasis and stem cell maintenance in the Drosophila testis
Published Date
Jun 1, 2019
Volume
21
Issue
6
Pages
710 - 720
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