Inhibition of the NKp44-PCNA Immune Checkpoint Using a mAb to PCNA
Abstract
mAb-based blocking of the immune checkpoints involving the CTLA4-B7 and PD1-PDL1 inhibitory axes enhance T-cell–based adaptive immune responses in patients with cancer. We show here that antitumor responses by natural killer (NK) cells can be enhanced by a checkpoint-blocking mAb, 14-25-9, which we developed against proliferating cell nuclear antigen (PCNA). PCNA is expressed on the surface of cancer cells and acts as an inhibitory ligand for...
Paper Details
Title
Inhibition of the NKp44-PCNA Immune Checkpoint Using a mAb to PCNA
Published Date
Jul 1, 2019
Journal
Volume
7
Issue
7
Pages
1120 - 1134
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Notes
History