Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patients
Abstract
Clinical data identified an association between the use of HMG-CoA reductase inhibitors (statins) and incident diabetes in patients with underlying diabetes risk factors such as obesity, hypertension and dyslipidemia. The molecular mechanisms however are unknown.An observational cross-sectional study included 910 severely obese patients, mean (SD) body mass index (BMI) 46.7 (8.7), treated with or without statins (ABOS cohort: a biological atlas...
Paper Details
Title
Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patients
Published Date
Jun 3, 2019
Journal
Volume
12
Issue
1
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