Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer
Abstract
Single-cell technologies have described heterogeneity across tissues, but the spatial distribution and forces that drive single-cell phenotypes have not been well defined. Combining single-cell RNA and protein analytics in studying the role of stromal cancer-associated fibroblasts (CAFs) in modulating heterogeneity in pancreatic cancer (pancreatic ductal adenocarcinoma [PDAC]) model systems, we have identified significant single-cell population...
Paper Details
Title
Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer
Published Date
Jun 1, 2019
Journal
Volume
178
Issue
1
Pages
160 - 175.e27
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