Alzheimer’s disease pathology: pathways between central norepinephrine activity, memory, and neuropsychiatric symptoms
Abstract
The locus coeruleus (LC) supplies norepinephrine to the brain, is one of the first sites of tau deposition in Alzheimer's disease (AD) and modulates a variety of behaviors and cognitive functions. Transgenic mouse models showed that norepinephrine dysregulation after LC lesions exacerbates inflammatory responses, blood-brain barrier leakage (BBB), and cognitive deficits. Here, we investigated relationships between central norepinephrine...
Paper Details
Title
Alzheimer’s disease pathology: pathways between central norepinephrine activity, memory, and neuropsychiatric symptoms
Published Date
May 28, 2019
Journal
Volume
26
Issue
3
Pages
897 - 906
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