Transcriptomic and Clinical Characterization of Neuropeptide Y Expression in Localized and Metastatic Prostate Cancer: Identification of Novel Prostate Cancer Subtype with Clinical Implications

Tumor microenvironment and its interaction with neuroendocrine modulators contribute to prostate carcinogenesis and progression. We sought to define the transcriptomic and clinical implications of neuropeptide Y (NPY) expression in prostate cancer progression. Genome-wide expression profiling of three localized prostate cancer (total n = 18 818) and five metastatic castrate-resistant prostate cancer (mCRPC; total n = 495) cohorts was used to...