Mechanism for oral tumor cell lysyl oxidase like-2 in cancer development: synergy with PDGF-AB
Abstract
Extracellular lysyl oxidases (LOX and LOXL1-LOXL4) are critical for collagen biosynthesis. LOXL2 is a marker of poor survival in oral squamous cell cancer. We investigated mechanisms by which tumor cell secreted LOXL2 targets proximal mesenchymal cells to enhance tumor growth and metastasis. This study identified the first molecular mechanism for LOXL2 in the promotion of cancer via its enzymatic modification of a non-collagenous substrate in...
Paper Details
Title
Mechanism for oral tumor cell lysyl oxidase like-2 in cancer development: synergy with PDGF-AB
Published Date
May 13, 2019
Journal
Volume
8
Issue
5
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