Limitations of Anti-Angiogenic Treatment of Tumors
Abstract
Clinical trials using anti-vascular endothelial growth factor /(VEGF) molecules induce a modest improvement in overall survival, measurable in weeks to just a few months, and tumors respond differently to these agents. In this review article, we have exposed some tumor characteristics and processes that may impair the effectiveness of anti-angiogenic approaches, including genotypic changes on endothelial cells, the vascular normalization...
Paper Details
Title
Limitations of Anti-Angiogenic Treatment of Tumors
Published Date
Jul 1, 2019
Journal
Volume
12
Issue
7
Pages
981 - 986
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Notes
History