Development of thermal-crosslinkable chitosan/maleic terminated polyethylene glycol hydrogels for full thickness wound healing: In vitro and in vivo evaluation

The aim of this study was to fabricate a hydrogel based therapy to accelerate full-thickness wound healing process. Hydrogel matrix was composed from of chitosan as backbone and maleic terminated polyethylene glycol (PEG-MA) as crosslinking agent. PEG-MA was synthesized through a reaction of PEG with maleic anhydride. For hydrogel preparation, various PEG-MA/chitosan ratios were assessed to find the optimum ratio. Further improvement on hydrogel...