Chondroitin sulfate from sturgeon bone protects chondrocytes via inhibiting apoptosis in osteoarthritis

We have previously reported that chondroitin sulfate extracted from Sturgeon bone (CSSB) can alleviate the pain caused by osteoarthritis (OA) by reducing the expression of matrix metalloproteinases (MMPs) and inflammatory factors (IL-1, TNF-α and PGE2). However, the mechanism of CSSB for treating OA remains unclear. As is generally accepted, these proteins and factors are regulated by chondrocyte apoptosis in OA. Thus, it is reasonable to...