The Expanding Role of MT1-MMP in Cancer Progression
Abstract
For over 20 years, membrane type 1 matrix metalloproteinase (MT1-MMP) has been recognized as a key component in cancer progression. Initially, the primary roles assigned to MT1-MMP were the activation of proMMP-2 and degradation of fibrillar collagen. Proteomics has revealed a great array of MT1-MMP substrates, and MT1-MMP selective inhibitors have allowed for a more complete mapping of MT1-MMP biological functions. MT1-MMP has extensive...
Paper Details
Title
The Expanding Role of MT1-MMP in Cancer Progression
Published Date
May 20, 2019
Journal
Volume
12
Issue
2
Pages
77 - 77
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Notes
History