Nephrin Signaling Results in Integrin β1 Activation

Volume: 30, Issue: 6, Pages: 1006 - 1019
Published: May 16, 2019
Abstract
Background Patients with certain mutations in the gene encoding the slit diaphragm protein Nephrin fail to develop functional slit diaphragms and display severe proteinuria. Many adult-onset glomerulopathies also feature alterations in Nephrin expression and function. Nephrin signals from the podocyte slit diaphragm to the Actin cytoskeleton by recruiting proteins that can interact with C3G, a guanine nucleotide exchange factor of the small...
Paper Details
Title
Nephrin Signaling Results in Integrin β1 Activation
Published Date
May 16, 2019
Volume
30
Issue
6
Pages
1006 - 1019
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