Polymicrobial Keratitis of Pseudomonas aeruginosa, Acinetobacter baumannii, and Ochrobactrum anthropi

Published on May 15, 2019in Journal of The Korean Ophthalmological Society
· DOI :10.3341/JKOS.2019.60.5.474
Jung Youb Kang1
Estimated H-index: 1
,
Ju Hwan Song1
Estimated H-index: 1
+ 2 AuthorsSang Joon Lee11
Estimated H-index: 11
(Kosin University)
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Abstract
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References13
Newest
#1Nandini Venkateswaran (UM: University of Miami)H-Index: 7
#2Rachel A. F. Wozniak (UR: University of Rochester)H-Index: 7
Last. Holly B. Hindman (UR: University of Rochester)H-Index: 14
view all 3 authors...
Purpose. To describe a unique case of O. anthropi keratitis associated with a rare manifestation of Descemet's membrane detachment and intracorneal hypopyon and to discuss challenges in diagnosis and management. Methods. Best-corrected visual acuity was measured with Snellen letters. Corneal scrapings were performed and aerobic, viral, herpetic, acid-fast bacilli, Acanthamoeba, and fungal stains and cultures were obtained. Following evisceration, tissue was evaluated for histologic features and ...
4 CitationsSource
#1Kyoung Yoon Shin (DU: Dankook University)H-Index: 1
#2Kyoung Jin Cho (DU: Dankook University)H-Index: 1
2 CitationsSource
#1Matthieu Eveillard (University of Angers)H-Index: 23
#2Marie Kempf (University of Angers)H-Index: 28
Last. Marie-Laure Joly-Guillou (University of Angers)H-Index: 24
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Summary The objective of the present report was to review briefly the potentially community-acquired Acinetobacter baumannii infections, to update information on the reservoirs of A. baumannii outside the hospital, and to consider their potential interactions with human infections. Most reports on potentially community-acquired A. baumannii have been published during the last 15 years. They concern community-acquired pneumonia, infections in survivors from natural disasters, and infected war wou...
89 CitationsSource
#1Jae Kwang Choi (Sahmyook Medical Center)H-Index: 1
#2In Hyuk Kim (Sahmyook Medical Center)H-Index: 2
Last. Jeong Won Seo (Sahmyook Medical Center)H-Index: 1
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3 CitationsSource
#1Patrick S. G. Chain (JGI: Joint Genome Institute)H-Index: 68
#2Dorothy M. Lang (LLNL: Lawrence Livermore National Laboratory)H-Index: 4
Last. Marcelo E. Tolmasky (CSUF: California State University, Fullerton)H-Index: 44
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Ochrobactrum anthropi is a common soil alphaproteobacterium that colonizes a wide spectrum of organisms and is being increasingly recognized as an opportunistic human pathogen. Potentially life-threatening infections, such as endocarditis, are included in the list of reported O. anthropi infections. These reports, together with the scant number of studies and the organism's phylogenetic proximity to the highly pathogenic brucellae, make O. anthropi an attractive model of bacterial pathogenicity....
39 CitationsSource
#1Chun-Chi Chiang (PRC: China Medical University (PRC))H-Index: 16
#2Yi-Yu Tsai (PRC: China Medical University (PRC))H-Index: 23
Last. Wen-Lu Chen (PRC: China Medical University (PRC))H-Index: 7
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8 CitationsSource
#1Bryan R. ThomaH-Index: 6
#2Eberhard Straube (Schiller International University)H-Index: 30
Last. Herbert TomasoH-Index: 41
view all 8 authors...
Ochrobactrum (O.) anthropi is an opportunistic emerging pathogen closely related to the genus Brucella. Identification and differentiation from brucellae and other Ochrobactrum spp. using routine biochemical test systems is not reliable due to the high phenotypic similarity. In this study, antibiotic susceptibilities of 103 Ochrobactrum isolates were determined using Etest (TM) for 19 clinically relevant antimicrobial agents. Ochrobactrum strains were highly resistant to beta-lactam antibiotics,...
36 CitationsSource
#1Seong Tek Kim (Chosun University)H-Index: 1
#2Young Chang Lee (Chosun University)H-Index: 2
Last. Jae Woong Koh (Chosun University)H-Index: 1
view all 4 authors...
Purpose: To report a case of Acinetobacter baumannii keratitis in a soft contact lens wearer. To our knowledge, such a case has not been previously reported in South Korea. Case summary: A 17-year-old boy who had worn soft contact lens for 4 months came to our hospital complaining of severe ocular pain, glare, and visual disturbance in his left eye for 2 days prior to admission. On slit-lamp examination, a round 2.5×4.5 mm lesion with epithelial defects and diffuse edema was noted. Numerous kera...
3 CitationsSource
#1Anton Y. Peleg (University of Pittsburgh)H-Index: 58
#2David L. Paterson (University of Pittsburgh)H-Index: 128
26 CitationsSource
We describe a case of infective endocarditis in a prosthetic mitral valve due to Ochrobactrum anthropi. Although O. anthropi is an emerging pathogen in immunocompromised patients, infections with the bacterium have very rarely been documented in healthy hosts, and endocarditis is rare. To our knowledge, only two cases of O. anthropi endocarditis have been reported in the medical literature.
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#1Michael P. Ryan (UL: University of Limerick)H-Index: 11
#2J. Tony Pembroke (UL: University of Limerick)H-Index: 19
Ochrobactrum species are non-enteric, Gram-negative organisms that are closely related to the genus Brucella. Since the designation of the genus in 1988, several distinct species have now been characterised and implicated as opportunistic pathogens in multiple outbreaks. Here, we examine the genus, its members, diagnostic tools used for identification, data from recent Ochrobactrum whole genome sequencing and the pathogenicity associated with reported Ochrobactrum infections. This review identif...
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#1Wesley Hebert (Dartmouth College)H-Index: 3
#2Antonio DiGiandomenico (AstraZeneca)H-Index: 3
Last. Michael E. Zegans (Dartmouth College)H-Index: 33
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A worrisome trend in the study and treatment of infectious disease noted in recent years is the increase in multidrug resistant strains of bacteria concurrent with a scarcity of new antimicrobial agents to counteract this rise. This is particularly true amongst bacteria within the Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species (ESKAPE) designation. P. aeruginosa is one of the most common causes of bact...
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