The knob protein KAHRP assembles into a ring-shaped structure that underpins virulence complex assembly
Abstract
Plasmodium falciparum mediates adhesion of infected red blood cells (RBCs) to blood vessel walls by assembling a multi-protein complex at the RBC surface. This virulence-mediating structure, called the knob, acts as a scaffold for the presentation of the major virulence antigen, P. falciparum Erythrocyte Membrane Protein-1 (PfEMP1). In this work we developed correlative STochastic Optical Reconstruction Microscopy-Scanning Electron Microscopy...
Paper Details
Title
The knob protein KAHRP assembles into a ring-shaped structure that underpins virulence complex assembly
Published Date
May 9, 2019
Journal
Volume
15
Issue
5
Pages
e1007761 - e1007761
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