Carbonate apatite granules with uniformly sized pores that arrange regularly and penetrate straight through granules in one direction for bone regeneration

Artificial bone substitutes that can solve the problems associated with autogenous bone grafts are essential. In this study, macroporous carbonate apatite (CO3Ap) granules with the same composition as natural bone were implanted into distal epiphysis defects in rabbit femurs. Material resorption and bone regeneration were then evaluated. The macroporous granules were obtained by extruding honeycomb (HC) structure rods containing calcium...