Label-free quantitation of glycated hemoglobin in single red blood cells by transient absorption microscopy and phasor analysis
Abstract
As a stable and accurate biomarker, glycated hemoglobin (HbA1c) is clinically used to diagnose diabetes with a threshold of 6.5% among total hemoglobin (Hb). Current methods such as boronate affinity chromatography involve complex processing of large-volume blood samples. Moreover, these methods cannot measure HbA1c fraction at single-red blood cell (RBC) level, thus unable to separate the contribution from other factors such as RBC lifetime....
Paper Details
Title
Label-free quantitation of glycated hemoglobin in single red blood cells by transient absorption microscopy and phasor analysis
Published Date
May 3, 2019
Journal
Volume
5
Issue
5
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