Deep grey matter involvement and altered sensory gating in multiple sclerosis

Background: Somatosensory temporal discrimination threshold (STDT) is altered in multiple sclerosis (MS). In healthy subjects (HS), voluntary movement modulates the STDT through mechanisms of subcortical sensory gating. Objective: With neurophysiological and magnetic resonance imaging (MRI) techniques, we investigated sensory gating and sensorimotor integration in MS. Methods: We recruited 38 relapsing-remitting multiple sclerosis (RR-MS)...