Hyaluronic acid for advanced therapies: Promises and challenges

Hyaluronic acid (HA), also termed hyaluronan, is a key extracellular matrix glycosaminoglycan that not only provides tissue hydration, but also shows intrinsic bioactivity towards cellular proliferation, differentiation and inflammatory response. These properties make HA attractive both as a potential target for the treatment of several diseases and as an effective biomaterial to control cell behavior. This concise review aims at emphasizing the...