Structural topology defines protective CD8 + T cell epitopes in the HIV proteome

Science56.90
Volume: 364, Issue: 6439, Pages: 480 - 484
Published: May 3, 2019
Abstract
Mutationally constrained epitopes of variable pathogens represent promising targets for vaccine design but are not reliably identified by sequence conservation. In this study, we employed structure-based network analysis, which applies network theory to HIV protein structure data to quantitate the topological importance of individual amino acid residues. Mutation of residues at important network positions disproportionately impaired viral...
Paper Details
Title
Structural topology defines protective CD8 + T cell epitopes in the HIV proteome
Published Date
May 3, 2019
Journal
Volume
364
Issue
6439
Pages
480 - 484
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