Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain.

Volume: 11, Issue: 490
Published: May 1, 2019
Abstract
The hallmarks of Alzheimer's disease (AD) are the accumulation of Aβ plaques and neurofibrillary tangles composed of hyperphosphorylated tau. We developed sensitive cellular assays using human embryonic kidney-293T cells to quantify intracellular self-propagating conformers of Aβ in brain samples from patients with AD or other neurodegenerative diseases. Postmortem brain tissue from patients with AD had measurable amounts of pathological Aβ...
Paper Details
Title
Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain.
Published Date
May 1, 2019
Volume
11
Issue
490
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