Prognostic Value of Cervical Nodal Necrosis Observed in Preoperative CT and MRI of Patients With Tongue Squamous Cell Carcinoma and Cervical Node Metastases: A Retrospective Study.

Published on Apr 30, 2019in American Journal of Roentgenology3.013
· DOI :10.2214/AJR.18.20405
Sung Hyun Baik3
Estimated H-index: 3
(Yonsei University),
Ji Won Seo2
Estimated H-index: 2
(Yonsei University)
+ 3 AuthorsJinna Kim28
Estimated H-index: 28
(Yonsei University)
Sources
Abstract
OBJECTIVE. The prognosis of tongue squamous cell carcinoma (SCC) with cervical lymph node metastases is poor, and a subset of patients with aggressive disease experiences treatment failure. The cur...
📖 Papers frequently viewed together
1 Citations
6 Citations
References11
Newest
#1M.G. Yoo (Yonsei University)H-Index: 1
#2Jinna Kim (Yonsei University)H-Index: 28
Last. Yoon Woo Koh (Yonsei University)H-Index: 24
view all 6 authors...
Aim To evaluate and compare the utility of contrast-enhanced three-dimensional (3D) T1-weighted high-resolution isotropic volume examination (THRIVE), spin-echo (SE) T1-weighted magnetic resonance imaging (MRI), and computed tomography (CT) for detecting clinically occult primary tumours in patients with cervical lymph node metastases. Materials and methods Seventy-three consecutive patients with tumours that went undetected during endoscopic or physical examinations underwent preoperative contr...
5 CitationsSource
#1Mei Lan (SYSU: Sun Yat-sen University)H-Index: 4
#2Ying Huang (SYSU: Sun Yat-sen University)H-Index: 11
Last. Tai Xiang LuH-Index: 25
view all 8 authors...
Cervical nodal metastasis is an independent negative prognostic factor in patients with nasopharyngeal carcinoma, and we suggest that it may be appropriate to investigate whether, in such patients, N stage should be upgraded by one level.
49 CitationsSource
#1Julia de Juan (Autonomous University of Barcelona)H-Index: 2
#2Jacinto GarcíaH-Index: 14
Last. Xavier LeónH-Index: 34
view all 7 authors...
Importance: The inclusion of data about the presence ofmetastaticnecknodeswithextracapsularspread(ECS) in the neck dissection improves the prognostic classification of patients with head and neck squamous cell carcinoma (HNSCC). Objective: To evaluate the prognostic capacity of ECS in patients with HNSCC, and to analyze the usefulness of including this information in the pathological classification of patients treated with a neck dissection. Design: Retrospective unicenter study performed from 1...
68 CitationsSource
#1Cheng Wang (UIC: University of Illinois at Chicago)H-Index: 20
#2Hongzhang Huang (SYSU: Sun Yat-sen University)H-Index: 19
Last. Xiqiang Liu (UIC: University of Illinois at Chicago)H-Index: 21
view all 8 authors...
J Oral Pathol Med (2011) 40: 545–551 Background: Tumor budding is a readily detectable histopathological feature and has been recognized as an adverse prognostic factor in several human cancers. However, the prognostic value of tumor budding in tongue squamous cell carcinoma (TSCC) has not been reported. The purpose of this study was to assess the correlation of tumor budding with the clinicopathologic features, and the known molecular biomarkers (E-cadherin and Vimentin), as well as to evaluate...
100 CitationsSource
#1Yan Ping Mao (SYSU: Sun Yat-sen University)H-Index: 43
#2Shao Bo Liang (SYSU: Sun Yat-sen University)H-Index: 10
Last. Jun MaH-Index: 110
view all 11 authors...
Purpose: To evaluate the prognostic value of variables including nodal size, level, laterality, extranodal neoplastic spread (ENS), and necrosis in patients with nasopharyngeal carcinoma (NPC) and further explore the feasibility of an N-staging system using Radiation Therapy Oncology Group (RTOG) guidelines for lymph node levels based on magnetic resonance imaging (MRI). Experimental Design: The MRI scans of 924 patients with histologically diagnosed nondisseminated NPC were reviewed retrospecti...
95 CitationsSource
#1Daisuke Sano (University of Texas MD Anderson Cancer Center)H-Index: 22
#2Jeffrey N. Myers (University of Texas MD Anderson Cancer Center)H-Index: 80
Squamous cell carcinoma of the oral tongue (SCCOT) is one of the most prevalent tumors of the head and neck region. Despite advances in treatment, the survival of patients with SCCOT has not significantly improved over the past several decades. Most frequently, treatment failure takes the form of local and regional recurrences, but as disease control in these areas improves, SCCOT treatment failures are occurring more often as distant metastasis. The presence of cervical lymph node metastasis is...
277 CitationsSource
#1Li Zhi Liu (SYSU: Sun Yat-sen University)H-Index: 29
#2Guo Yi Zhang (SYSU: Sun Yat-sen University)H-Index: 4
Last. Li Li (SYSU: Sun Yat-sen University)H-Index: 59
view all 6 authors...
Purpose: To investigate the incidence, distribution, and spread pattern of retropharyngeal lymph node (RLN) involvement in patients with nasopharyngeal carcinoma (NPC) by using magnetic resonance imaging (MRI). Methods and Materials: The MR images of 275 patients with newly diagnosed NPC were reviewed retrospectively. Nodes were classified as metastatic based on size criteria, the presence of nodal necrosis, and extracapsular spread. Results: Retropharyngeal lymph node involvement was detected i...
84 CitationsSource
#1Margaret Brandwein-Gensler (Mount Sinai Hospital)H-Index: 29
#2Miriam S. Teixeira (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 11
Last. Beverly Y. Wang (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 28
view all 9 authors...
Abstract:To analyze the impact of resection margin status and histologic prognosticators on local recurrence (LR) and overall survival (OS) for patients with oral squamous cell carcinoma (OSCC). This study was both retrospective and prospective in design. Cohort 1 refers to the entire group of 292 p
523 CitationsSource
#1Jayson S. Greenberg (BCM: Baylor College of Medicine)H-Index: 2
#2Robert Fowler (University of Texas MD Anderson Cancer Center)H-Index: 1
Last. Jeffrey N. Myers (University of Texas MD Anderson Cancer Center)H-Index: 80
view all 7 authors...
BACKGROUND Extracapsular spread (ECS) of metastatic squamous cell carcinoma of the head and neck to regional lymph nodes is the most reliable predictor of poor treatment outcomes. Recently, the authors have shown that ECS is significantly associated with higher rates of locoregional recurrence, distant metastasis, and decreased survival in patients with squamous cell carcinoma of the oral tongue (SCCOT). The purpose of this review was to determine if the degree of ECS impacts distant metastasis ...
198 CitationsSource
#1C Martínez-GimenoH-Index: 1
#2E M RodríguezH-Index: 1
Last. Carmen Lopez VarelaH-Index: 1
view all 4 authors...
A series of 126 cases of squamous cell carcinoma of the oral cavity with neck dissection was studied. Several clinicohistologic parameters and statistical correlation with lymph node metastasis were evaluated. Statistical association with metastasis was found in the following factors : microvascular invasion (P<6 X 10 -7 ), grade of differentiation (P< .0001), T category (P =.003), tumor thickness (P = .005), inflammatory infiltration (P =.011), tumoral interphase (P =.02), and perineural spread...
135 CitationsSource
Cited By6
Newest
#1Reza Assadsangabi (UC Davis: University of California, Davis)
#2Rosa Babaei (UPenn: University of Pennsylvania)
Last. Seyed Ali Nabavizadeh (UPenn: University of Pennsylvania)H-Index: 11
view all 7 authors...
Involvement of lymph nodes in patients with head and neck cancers impacts treatment and prognosis. Head and neck lymph nodes are comprised of superficial and deep groups which are interconnected. The deep lymph nodes, predominantly centered along internal jugular veins, are very well-known to radiologists and clinicians. However, superficial lymph nodes that drain lymph from the scalp, face, and neck are much less recognized. Here, we describe the anatomic and imaging features of these superfici...
Source
Source
#1Shang-Hung Chen (NHRI: National Health Research Institutes)H-Index: 1
#2Sheng-Yen HsiaoH-Index: 1
Last. Jang Yang ChangH-Index: 60
view all 4 authors...
Oral squamous cell carcinoma (SCC) is a prevalent malignant disease worldwide, especially so in Taiwan. Early- or even preclinical-stage detection is critical for reducing morbidity and mortality from oral SCC. Epidemiological and genome association studies are useful for identifying clinicopathological risk factors for preventive, diagnostic, and therapeutic approaches of oral SCC. For advanced oral SCC, effective treatments are critical to prolonging survival and enhancing quality of life. As ...
5 CitationsSource
Purpose: To assess whether the three-dimensional reconstructions of preoperative computed tomography (CT) scans are helpful for establishing extranodal extension (ENE) in head and neck carcinoma. Approach: Patients with a histological diagnosis of ENE (pENE + ) were considered “cases” and patients with negative histological examination for ENE (pENE − ) were considered “controls.” Cases and controls were divided into two groups: a major nodes (MaN) group (lymph nodes on CT > 15 mm) and a minor n...
1 CitationsSource
view all 6 authors...
Source
#1Abhishek Mahajan (ACTREC: Tata Memorial Hospital)H-Index: 16
#2Ankita Ahuja (ACTREC: Tata Memorial Hospital)H-Index: 2
Last. Hilda E. Stambuk (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 24
view all 4 authors...
Abstract This review aims at simplifying the relevant imaging anatomy, guiding the optimal imaging method and highlighting the key imaging findings that influence prognosis and management of oral cavity squamous cell carcinoma (OSCC). Early OSCC can be treated with either surgery alone while advanced cancers are treated with a combination of surgery, radiotherapy and/or chemotherapy. Considering the complex anatomy of the oral cavity and its surrounding structures, imaging plays an indispensable...
4 CitationsSource