Zebrafishmab21l2mutants possess severe defects in optic cup morphogenesis, lens and cornea development
Abstract
Background Mutations in MAB21L2 result in severe ocular defects including microphthalmia, anophthalmia, coloboma, microcornea, and cataracts. The molecular and cellular underpinnings of these defects are unknown, as is the normal cellular function of MAB21L2. Zebrafish mab21l2 au10 mutants possess ocular defects resembling those in humans with MAB21L2 mutations, providing an excellent model to characterize mab21l2 functions during eye...
Paper Details
Title
Zebrafishmab21l2mutants possess severe defects in optic cup morphogenesis, lens and cornea development
Published Date
May 21, 2019
Journal
Volume
248
Issue
7
Pages
514 - 529
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