The NLRP3 inflammasome: molecular activation and regulation to therapeutics
Abstract
NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is an intracellular sensor that detects a broad range of microbial motifs, endogenous danger signals and environmental irritants, resulting in the formation and activation of the NLRP3 inflammasome. Assembly of the NLRP3 inflammasome leads to caspase 1-dependent release of the pro-inflammatory cytokines IL-1β and IL-18, as well as to gasdermin D-mediated pyroptotic cell death. Recent...
Paper Details
Title
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
Published Date
Apr 29, 2019
Journal
Volume
19
Issue
8
Pages
477 - 489
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