Association of Intrathecal Immunoglobulin G Synthesis With Disability Worsening in Multiple Sclerosis

Importance

Reliable biomarkers associated with disability worsening in multiple sclerosis (MS) are still needed.

Objective

To determine a possible association of intrathecal IgG synthesis and early disability worsening as measured by Expanded Disability Status Scale (EDSS) scoring in patients with relapsing-remitting MS or clinically isolated syndrome.

Design, Setting, and Participants

Cerebrospinal fluid measurements...