Recombinant human arginase I elicited immunosuppression in activated macrophages through inhibiting autophagy

Volume: 103, Issue: 12, Pages: 4825 - 4838
Published: May 3, 2019
Abstract
Arginase I has been documented to impair T cell function and attenuate cellular immunity, however, there is little evidence to reveal the effect of arginase I on macrophage function. Recently, recombinant human arginase I (rhArg) has been developed for cancer therapy and is in clinical trial for hepatocellular carcinoma, whereas the potential immunosuppression induced by rhArg limited its therapeutic efficacy. To improve the clinical outcome of...
Paper Details
Title
Recombinant human arginase I elicited immunosuppression in activated macrophages through inhibiting autophagy
Published Date
May 3, 2019
Volume
103
Issue
12
Pages
4825 - 4838
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