Synthesis, biological evaluation and computational studies of fused acridine containing 1,2,4-triazole derivatives as anticancer agents
Abstract
A novel series of fused acridine containing 1,2,4-triazole derivatives (13a-j) have been synthesized and their structures were confirmed by 1HNMR, 13CNMR and mass spectral data. Further, all these derivatives were tested for their anticancer activity against four human cancer cell lines A549 (Lung), MCF7 (Breast), A375 (Melanoma) and HT-29 (Colon). The IC50 values range of target compounds shown 0.11 ± 0.02 to 13.8 ± 0.99 µM as compared with...
Paper Details
Title
Synthesis, biological evaluation and computational studies of fused acridine containing 1,2,4-triazole derivatives as anticancer agents
Published Date
May 3, 2019
Journal
Volume
49
Issue
13
Pages
1729 - 1740
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