Terminal ileum ileoscopy and histology in patients undergoing high‐definition colonoscopy with virtual chromoendoscopy for chronic nonbloody diarrhea: A prospective, multicenter study

Background and aims Ileo‐colonoscopy is the procedure of choice for chronic nonbloody diarrhea (CNBD) of unknown origin. Histological evaluation at different colonic sites is mandatory to assess the presence of microscopic colitis. However, the value of routine ileal biopsy on normal‐appearing mucosa as assessed by means of standard‐resolution white‐light ileoscopy is controversial given its reported low diagnostic yield. Hence, we have assessed...