Critical role of IL-21 and T follicular helper cells in hypertension and vascular dysfunction
Abstract
T and B cells have been implicated in hypertension, but the mechanisms by which they produce a coordinated response is unknown. T follicular helper (Tfh) cells that produce IL-21 promote germinal center (GC) B cell responses, leading to Ig production. Here we investigate the role of IL-21 and Tfh cells in hypertension. In response to angiotensin II–induced (Ang II–induced) hypertension, T cell IL-21 production was increased, and Il21–/– mice...
Paper Details
Title
Critical role of IL-21 and T follicular helper cells in hypertension and vascular dysfunction
Published Date
Jun 6, 2019
Journal
Volume
4
Issue
11
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