QSAR modelling on a series of arylsulfonamide-based hydroxamates as potent MMP-2 inhibitors

Volume: 30, Issue: 4, Pages: 247 - 263
Published: Apr 3, 2019
Abstract
Matrix metalloproteinase-2 (MMP-2) is a lucrative therapeutic target as far as anticancer drug discovery is concerned. Overexpression of MMP-2 is found to facilitate tumour propagation through the involvement of vascular endothelial growth factor (VEGF). However, even after different techniques, finding a target-specific MMP-2 inhibitor with respectable pharmacodynamic properties is still a challenging task. Regression-dependent quantitative...
Paper Details
Title
QSAR modelling on a series of arylsulfonamide-based hydroxamates as potent MMP-2 inhibitors
Published Date
Apr 3, 2019
Volume
30
Issue
4
Pages
247 - 263
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