Optics

Physics

Cell signaling

Crosstalk

Organic chemistry

Chemistry

Calcium signaling

Cellular metabolism

Signalling

Reactive oxygen species

Calcium

Biochemistry

Metabolism

Signal transduction

Homeostasis

Biology

Calcium metabolism

Cell biology

Oxidative Medicine and Cellular Longevity

Calcium ions are highly versatile intracellular signals that regulate many cellular processes. The key to achieving this pleiotropic role is the spatiotemporal control of calcium concentration evoked by an extensive molecular repertoire of signalling components. Among these, reactive oxygen species (ROS) signalling, together with calcium signalling, plays a crucial role in controlling several physiopathological events. Although initially considered detrimental by-products of aerobic metabolism, it is now widely accepted that ROS, in subtoxic levels, act as signalling molecules. However, dysfunctions in the mechanisms controlling the physiological ROS concentration affect cellular homeostasis, leading to the pathogenesis of various disorders.

Crosstalk between Calcium and ROS in Pathophysiological Conditions