Icariin attenuate microcystin-LR-induced gap junction injury in Sertoli cells through suppression of Akt pathways
Abstract
Microcystin-leucine-arginine (MC-LR) can cause male reproductive disorder. However, the underlying mechanism are not yet entirely elucidated. In this study, we aimed to investigated the effects of MC-LR on the integrity of blood-testis barrier (BTB) and the related molecular mechanisms. Both in vivo and in vitro experiments revealed that MC-LR caused disruption of BTB and gap junctions between Sertoli cells respectively, which was paralleled by...
Paper Details
Title
Icariin attenuate microcystin-LR-induced gap junction injury in Sertoli cells through suppression of Akt pathways
Published Date
Aug 1, 2019
Journal
Volume
251
Pages
328 - 337
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