Hairpin and allosteric regulation in ADAMTS13

In this issue of null Blood , Muia et al 1 null and Zhu et al, 2 null using complementary approaches, provide important insights into the structure and function of ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin-1 repeats, member 13), identifying critical structural features and interactions that allosterically regulate its proteolytic activity on von Willebrand factor...