Resveratrol Promotes Diabetic Wound Healing via SIRT1-FOXO1-c-Myc Signaling Pathway-Mediated Angiogenesis

Background/Aims: Diabetic foot ulcers (DFUs) represent a serious challenge in clinical practice, in which the hyperglycemia-induced disturbance of angiogenesis and endothelial dysfunction play a crucial role. Resveratrol (RES), a potential agonist of silent information regulator 1 (SIRT1), can improve endothelial function and has strong pro-angiogenic properties, thus becoming a research focus for the treatment of DFUs; however, the underlying...