<p>Intrathecal TRPM8 blocking attenuates cold hyperalgesia via PKC and NF-&kappa;B signaling in the dorsal root ganglion of rats with neuropathic pain</p>
Abstract
Background: TRPM8 channel plays central roles in the sensitization of nociceptive transduction and is thought as one of the potential targets for the treatment of neuropathic pain. However, the specific molecular mechanisms are still less clear. Methods: Sciatic chronic constriction injury (CCI) rats were intrathecally administered with AMTB (TRPM8-selective antagonist) or PDTC (nuclear factor-kappa B (NF-κB) inhibitor). Cold-, thermal- and...
Paper Details
Title
<p>Intrathecal TRPM8 blocking attenuates cold hyperalgesia via PKC and NF-&kappa;B signaling in the dorsal root ganglion of rats with neuropathic pain</p>
Published Date
Apr 1, 2019
Journal
Volume
Volume 12
Pages
1287 - 1296
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Notes
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