Localization of liver lesions in abdominal CT imaging: II. Mathematical model observer performance correlates with human observer performance for localization of liver lesions in abdominal CT imaging

Determination of the effect of protocol modifications on diagnostic performance in CT with human observers is extremely time-consuming, limiting the applicability of such methods in routine clinical practice. In this work, we sought to determine whether a channelized Hotelling observer (CHO) could predict human observer performance for the task of liver lesion localization as background, reconstruction algorithm, dose, and lesion size were...