Neonatal Fc receptor expression in macrophages is indispensable for IgG homeostasis
Abstract
The maintenance of the homeostasis of immunoglobulin G (IgG) represents a fundamental aspect of humoral immunity that has direct relevance to the successful delivery of antibody-based therapeutics. The ubiquitously expressed neonatal Fc receptor (FcRn) salvages IgG from cellular degradation following pinocytic uptake into cells, conferring prolonged in vivo persistence on IgG. However, the cellular sites of FcRn function are poorly defined....
Paper Details
Title
Neonatal Fc receptor expression in macrophages is indispensable for IgG homeostasis
Published Date
Apr 30, 2019
Journal
Volume
11
Issue
5
Pages
848 - 860
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Notes
History