Dural Calcitonin Gene-Related Peptide Produces Female-Specific Responses in Rodent Migraine Models
Abstract
Migraine is the second leading cause for disability worldwide and the most common neurological disorder. It is also three times more common in women; reasons for this sex difference are not known. Using preclinical behavioral models of migraine, we show that application of calcitonin gene-related peptide (CGRP) to the rat dura mater produces cutaneous periorbital hypersensitivity. Surprisingly, this response was observed only in females; dural...
Paper Details
Title
Dural Calcitonin Gene-Related Peptide Produces Female-Specific Responses in Rodent Migraine Models
Published Date
Apr 8, 2019
Journal
Volume
39
Issue
22
Pages
4323 - 4331
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