Impaired cellular energy metabolism in cord blood macrophages contributes to abortive response toward inflammatory threats
Abstract
Neonatal sepsis is characterized by hyperinflammation causing enhanced morbidity and mortality compared to adults. This suggests differences in the response towards invading threats. Here we investigate activated cord blood macrophages (CBMΦ) in comparison to adult macrophages (PBMΦ), indicating incomplete interferon gamma (IFN-γ) and interleukin 10 (IL-10)-induced activation of CBMΦ. CBMΦ show reduced expression of phagocytosis receptors and...
Paper Details
Title
Impaired cellular energy metabolism in cord blood macrophages contributes to abortive response toward inflammatory threats
Published Date
Apr 11, 2019
Journal
Volume
10
Issue
1
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