Osteoarthritic milieu and hypoxia exert specific effects on adipose mesenchymal stromal cell migration and cytokine receptor expression

Purpose: Cell-based therapies using mesenchymal stem cells from adipose tissue (ASC) showed promising results for the treatment of osteoarthritis (OA), that is a whole joint disease characterized by progressive degeneration of articular cartilage, inflammation of the synovium, and subchondral bone changes. ASC are commonly utilized in various cell therapies and recently in phase I clinical trials to counteract the development of knee...