Role of gene promoter methylation regulated by TETs and DNMTs in the overexpression of HLA‑G in MCF‑7 cells

Human leukocyte antigen‑G (HLA‑G) is highly expressed in numerous solid tumor cell types and has important roles in protecting tumor cells from host immune recognition and destruction. DNA methylation modification, which may regulate gene expression, is aberrant in numerous tumor cell types. However, whether the high expression of HLA‑G in tumor cells is induced by aberrant DNA methylation has remained elusive. In the present study, HLA‑G, DNA...