Lipotoxicity reduces β cell survival through islet stellate cell activation regulated by lipid metabolism-related molecules
Abstract
Islet stellate cells (ISCs) activation is mainly associated with islet fibrosis, which contributes to the progression of type 2 diabetes. However, the molecular mechanism underlying this process is not fully understood. In order to investigate this process the current study examined ectopic fat accumulation in rats with high-fat diet (HFD) induced obesity. Levels of lipotoxicity-induced ISC activation and islet function were assessed via...
Paper Details
Title
Lipotoxicity reduces β cell survival through islet stellate cell activation regulated by lipid metabolism-related molecules
Published Date
Jul 1, 2019
Journal
Volume
380
Issue
1
Pages
1 - 8
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