Organic chemistry

Lysine

Methionine

Biology

Gene

Biophysics

Protein domain

Chemistry

Methionine sulfoxide

Tyrosine

Methionine sulfoxide reductase

Yeast

Amino acid

Hydrogen peroxide

Biochemistry

Redox

Cell

Many proteins that are able to undergo phase transitions contain repeats rich in hydrophobic residues. By contrast, yeast ataxin-2 condensates rely on an abundance of methionines, providing a means for redox-sensitive regulation of its material properties.

Redox State Controls Phase Separation of the Yeast Ataxin-2 Protein via Reversible Oxidation of Its Methionine-Rich Low-Complexity Domain