N6-methylation of adenosine (m6A) of FZD10 mRNA contributes to PARP inhibitor resistance
Abstract
Despite the high initial response rates to PARP inhibitors (PARPi) in BRCA-mutated epithelial ovarian cancers (EOC), PARPi resistance remains a major challenge. null Chemical modifications of RNAs have emerged as a new layer of epigenetic gene regulation. N6-methyladenosine (m6A) is the most abundant chemical modification of messenger RNA (mRNA), yet the role of m6A modification in PARPi resistance has not previously been explored. null Here we...
Paper Details
Title
N6-methylation of adenosine (m6A) of FZD10 mRNA contributes to PARP inhibitor resistance
Published Date
Jun 1, 2019
Journal
Volume
79
Issue
11
Pages
2812 - 2820
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