Mutagenesis computer experiments in pentameric ligand-gated ion channels: the role of simulation tools with different resolution
Abstract
Pentameric ligand-gated ion channels (pLGICs) are an important class of widely expressed membrane neuroreceptors, which play a crucial role in fast synaptic communications and are involved in several neurological conditions. They are activated by the binding of neurotransmitters, which trigger the transmission of an electrical signal via facilitated ion flux. They can also be activated, inhibited or modulated by a number of drugs. Mutagenesis...
Paper Details
Title
Mutagenesis computer experiments in pentameric ligand-gated ion channels: the role of simulation tools with different resolution
Published Date
Apr 19, 2019
Journal
Volume
9
Issue
3
Pages
20180067 - 20180067
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