HHC-36 antimicrobial peptide loading on silk fibroin (SF)/hydroxyapatite (HA) nanofibrous-coated titanium for the enhancement of osteoblast and bactericidal functions

Improving osseointegration together with preventing infections are the main challenges of using titanium-based implants in joint replacement surgeries. In this study, a hybrid composite of silk fibroin (SF)/hydroxyapatite (HA) nanofibrous mats was directly electrospun on titanium plates in order to mimic the bone extracellular structure and improve osteoconductivity. Afterwards, HHC-36 antimicrobial peptide (AMP) was immobilized on the...